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Bousquet, J.* ; Antò, J.M.* ; Akdis, M.* ; Auffray, C.* ; Keil, T.* ; Momas, I.* ; Postma, D.* ; Valenta, R.* ; Wickman, M.* ; Cambon-Thomsen, A.* ; Haahtela, T.* ; Lambrecht, B.N.* ; Lodrup-Carlsen, K.* ; Koppelman, G.H.* ; Sunyer, J.* ; Zuberbier, T.* ; Annesi-Maesano, I.* ; Arno, A.* ; Bindslev-Jensen, C.* ; de Carlo, G.* ; Forastiere, F.* ; Heinrich, J. ; Kowalski, M.L.* ; Maier, D.* ; Melén, E.* ; Palkonen, S.* ; Smit, H.A.* ; Standl, M. ; Wright, J.* ; Arsanoj, A.* ; Benet, M.* ; Balardini, N.* ; Garcia-Aymerich, J.* ; Gehring, U.* ; Guerra, S.* ; Hohman, C.* ; Kull, I.* ; Lupinek, C.* ; Pinart, M.* ; Skrindo, I.* ; Westman, M.* ; Smagghe, D.* ; Akdis, C.* ; Albang, R.* ; Anastasova, V.* ; Anderson, N.* ; Bachert, C.* ; Ballereau, S.* ; Ballester, F.* ; Basagana, X.* ; Bedbrook, A.* ; Bergström, A.* ; von Berg, A.* ; Brunekreef, B.* ; Burte, E.* ; Carlsen, K.H.* ; Chatzi, L.* ; Coquet, J.M.* ; Curin, M.* ; Demoly, P.* ; Eller, E.* ; Fantini, M.P.* ; Gerhard, B.* ; Hammad, H.* ; von Hertzen, L.* ; Hovland, V.* ; Jacquemin, B.* ; Just, J.* ; Keller, T.* ; Kerkhof, M.* ; Kiss, R.* ; Kogevinas, M.* ; Koletzko, S.* ; Lau, S.* ; Lehmann, I.* ; Lemonnier, N.* ; McEachan, R.* ; Makela, M.J.* ; Mestres, J.* ; Minina, E.* ; Mowinckel, P.* ; Nadif, R.* ; Nawijn, M.C.* ; Oddie, S.* ; Pellet, J.* ; Pin, I.* ; Porta, D.* ; Ranciere, F.* ; Rial-Sebbag, A.* ; Saes, Y.* ; Schuijs, M.J.* ; Siroux, V.* ; Tischer, C.G. ; Torrent, M.* ; Varraso, R.* ; de Vocht, J.* ; Wenger, K.* ; Wieser, S.* ; Xu, C.*

Paving the way of systems biology and precision medicine in allergic diseases: The MeDALL success story Mechanisms of the Development of ALLergy; EUFP7-CP-IP; Project No: 261357; 2010-2015.

Allergy 71, 1513-1525 (2016)
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Open Access Green
MeDALL Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 20 (10) -2015 proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy(.) MeDALL linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology omics, IgE measurement using micro-arrays and environmental data(.) Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitisation(.) IgE sensitisation should be considered differently in mono and polysensitized individuals(.) Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases(.) Environmental exposures are relevant for the development of allergy-related diseases(.) To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans(.) The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases(.) Ethics and gender were considered(.) MeDALL had translational activities deployed within the EU agenda(.)
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Publication type Article: Journal article
Document type Review
Keywords Asthma ; Ige ; Multimorbidity ; Polysensitization ; Rhinitis; Chronic Respiratory-diseases; European Innovation Partnership; Birth Cohort; Childhood Asthma; Atopic-dermatitis; Immunological Reactivity; Ige Sensitization; Immune-responses; Immunoglobulin-e; Integrated Care
Language english
Publication Year 2016
HGF-reported in Year 2016
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Journal Allergy
Quellenangaben Volume: 71, Issue: 11, Pages: 1513-1525 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place Hoboken
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
Research field(s) Genetics and Epidemiology
PSP Element(s) G-503900-001
DOI 10.1111/all.12880
WOS ID WOS:000386083700001
Scopus ID 84990872120
PubMed ID 26970340
Erfassungsdatum 2016-03-14
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