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Parmar, P.G.* ; Taal, H.R.* ; Timpson, N.J.* ; Thiering, E. ; Lehtimäki, T.* ; Marinelli, M.* ; Lind, P.A.* ; Howe, L.D.* ; Verwoert, G.* ; Aalto, V.* ; Uitterlinden, A.G.* ; Briollais, L.* ; Evans, D.M* ; Wright, M.J.* ; Newnham, J.P.* ; Whitfield, J.B.* ; Lyytikäinen, L.-P.* ; Rivadeneira, F.* ; Boomsma, D.I.* ; Viikari, J.* ; Gillman, M.W.* ; St Pourcain, B.* ; Hottenga, J.J.* ; Montgomery, G.W.* ; Hofman, A.* ; Kähönen, M.* ; Martin, N.G.* ; Tobin, M.D.* ; Raitakari, O.* ; Vioque, J.* ; Jaddoe, V.W.* ; Jarvelin, M.R.* ; Beilin, L.J.* ; Heinrich, J. ; van Duijn, C.M.* ; Pennell, C.E.* ; Lawlor, D.A.* ; Palmer, L.J.*

International genome-wide association study consortium identifies novel loci associated with blood pressure in children and adolescents.

Circ. Cardiovasc. Genet. 9, 266-278 (2016)
Publ. Version/Full Text DOI PMC
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BACKGROUND: -Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence. METHODS AND RESULTS: -Genome-wide association study data from participating European ancestry cohorts of the EAGLE ( EA: rly G: enetics and L: ifecourse E: pidemiology) Consortium was meta-analysed across three 'epochs'; pre-puberty [4-7 years], puberty [8-12 years] and post-puberty [13-20 years]. Two novel loci were identified as having genome-wide associations with systolic blood pressure across specific age epochs; rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor CHiP and CpG methylation site) during pre-puberty (p = 2.86 × 10(-8)) and rs872256 during puberty (p = 8.67 × 10(-9)). Several SNP 'clusters' were also associated with childhood BP at p < 5 × 10(-3). Using a p-value threshold of < 5 × 10(-3) we found some overlap in variants across the different age epochs within our study, and between several SNPs in any of the three epochs and adult BP related SNPs. CONCLUSIONS: -Our results suggest that genetic determinants of blood pressure act from childhood, develop over the lifecourse, and show some evidence of age-specific effects.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Genome Wide Association Study ; Blood Pressure ; Children ; Genetic Epidemiology ; Hypertension ; Prehypertension; Coronary-artery-disease; Vascular Endothelial-cells; Gene-centric Metaanalysis; Candidate Genes; Iga Nephropathy; Common Variants; Atherothrombotic Stroke; Cardiovascular Risk; Pulse Pressure; Functional Snp
ISSN (print) / ISBN 1942-325X
e-ISSN 1942-3268
Journal Circulation: Cardiovascular Genetics
Quellenangaben Volume: 9, Issue: 3, Pages: 266-278 Article Number: , Supplement: ,
Publisher Lippincott Williams & Wilkins
Publishing Place Hagerstown, Md
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)