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Fujikawa, Y.* ; Roma, L.P.* ; Sobotta, M.C.* ; Rose, A.J.* ; Berriel Diaz, M. ; Locatelli, G.* ; Breckwoldt, M.O.* ; Misgeld, T.* ; Kerschensteiner, M.* ; Herzig, S. ; Müller-Decker, K.* ; Dick, T.P.*

Mouse redox histology using genetically encoded probes.

Sci. Signal. 9:rs1 (2016)
Publ. Version/Full Text Postprint DOI PMC
Open Access Green
Mapping the in vivo distribution of endogenous oxidants in animal tissues is of substantial biomedical interest. Numerous health-related factors, including diet, physical activity, infection, aging, toxins, or pharmacological intervention, may cause redox changes. Tools are needed to pinpoint redox state changes to particular organs, tissues, cell types, and subcellular organelles. We describe a procedure that preserves the in vivo redox state of genetically encoded redox biosensors within histological tissue sections, thus providing "redox maps" for any tissue and comparison of interest. We demonstrate the utility of the technique by visualizing endogenous redox differences and changes in the context of tumor growth, inflammation, embryonic development, and nutrient starvation.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Hydrogen-peroxide; In-vivo; Oxidative Stress; Stem-cells; H2o2; Mitohormesis; Homeostasis; Drosophila; Hyper
Language
Publication Year 2016
HGF-reported in Year 2016
ISSN (print) / ISBN 1945-0877
e-ISSN 1937-9145
Journal Science Signaling
Quellenangaben Volume: 9, Issue: 419, Pages: , Article Number: rs1 Supplement: ,
Publisher American Association for the Advancement of Science (AAAS)
Publishing Place Washington
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-501900-253
DOI 10.1126/scisignal.aad3895
WOS ID WOS:000372082400003
PubMed ID 26980443
Erfassungsdatum 2016-03-23
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