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Mouse redox histology using genetically encoded probes.
Sci. Signal. 9:rs1 (2016)
Mapping the in vivo distribution of endogenous oxidants in animal tissues is of substantial biomedical interest. Numerous health-related factors, including diet, physical activity, infection, aging, toxins, or pharmacological intervention, may cause redox changes. Tools are needed to pinpoint redox state changes to particular organs, tissues, cell types, and subcellular organelles. We describe a procedure that preserves the in vivo redox state of genetically encoded redox biosensors within histological tissue sections, thus providing "redox maps" for any tissue and comparison of interest. We demonstrate the utility of the technique by visualizing endogenous redox differences and changes in the context of tumor growth, inflammation, embryonic development, and nutrient starvation.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Hydrogen-peroxide; In-vivo; Oxidative Stress; Stem-cells; H2o2; Mitohormesis; Homeostasis; Drosophila; Hyper
ISSN (print) / ISBN
1945-0877
e-ISSN
1937-9145
Journal
Science Signaling
Quellenangaben
Volume: 9,
Issue: 419,
Article Number: rs1
Publisher
American Association for the Advancement of Science (AAAS)
Publishing Place
Washington
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Cancer (IDC)