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Kermanizadeh, A.* ; Gosens, I.* ; MacCalman, L.* ; Johnston, H.* ; Danielsen, P.H.* ; Jacobsen, N.R.* ; Lenz, A.-G. ; Fernandes, T.F.* ; Schins, R.P.* ; Cassee, F.R.* ; Wallin, H.* ; Kreyling, W.G. ; Stöger, T. ; Loft, S.* ; Møller, P.* ; Tran, L.* ; Stone, V.*

A multilaboratory toxicological assessment of a panel of 10 engineered nanomaterials to human health - ENPRA project - the highlights, limitations, and current and future challenges.

J. Toxicol. Environ. Health B Crit. Rev. 19, 1-28 (2016)
Postprint DOI PMC
Open Access Green
ENPRA was one of the earlier multidisciplinary European Commission FP7-funded projects aiming to evaluate the risks associated with nanomaterial (NM) exposure on human health across pulmonary, cardiovascular, hepatic, renal, and developmental systems. The outputs from this project have formed the basis of this review. A retrospective interpretation of the findings across a wide range of in vitro and in vivo studies was performed to identify the main highlights from the project. In particular, focus was placed on informing what advances were made in the hazard assessment of NM, as well as offering some suggestions on the future of "nanotoxicology research" based on these observations, shortcomings, and lessons learned from the project. A number of issues related to the hazard assessment of NM are discussed in detail and include use of appropriate NM for nanotoxicology investigations; characterization and dispersion of NM; use of appropriate doses for all related investigations; need for the correct choice of experimental models for risk assessment purposes; and full understanding of the test systems and correct interpretation of data generated from in vitro and in vivo systems. It is hoped that this review may assist in providing information in the implementation of guidelines, model systems, validation of assessment methodology, and integrated testing approaches for risk assessment of NM. It is vital to learn from ongoing and/or completed studies to avoid unnecessary duplication and offer suggestions that might improve different aspects of experimental design.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Multiwalled Carbon Nanotubes; Particulate Air-pollution; Short-term Inhalation; Amorphous Silica Nanoparticles; Titanium-dioxide Nanoparticles; Cell-line Cytotoxicity; In-vitro Assessment; Silver Nanoparticles; Gold Nanoparticles; Intratracheal Instillation
Language
Publication Year 2016
HGF-reported in Year 2016
ISSN (print) / ISBN 1093-7404
e-ISSN 1521-6950
Journal Journal of Toxicology and Environmental Health, Part B: Critical reviews
Quellenangaben Volume: 19, Issue: 1, Pages: 1-28 Article Number: , Supplement: ,
Publisher Taylor & Francis
Publishing Place Bristol
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Lung Research
Genetics and Epidemiology
PSP Element(s) G-505000-001
G-504000-001
DOI 10.1080/10937404.2015.1126210
WOS ID WOS:000373782300001
Scopus ID 84963635445
PubMed ID 27030582
Erfassungsdatum 2016-04-15
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