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The H1 linker histones: Multifunctional proteins beyond the nucleosomal core particle.
EMBO Rep. 16, 1439-1453 (2015)
The linker histone H1 family members are a key component of chromatin and bind to the nucleosomal core particle around the DNA entry and exit sites. H1 can stabilize both nucleosome structure and higher-order chromatin architecture. In general, H1 molecules consist of a central globular domain with more flexible tail regions at both their N- and C-terminal ends. The existence of multiple H1 subtypes and a large variety of posttranslational modifications brings about a considerable degree of complexity and makes studying this protein family challenging. Here, we review recent progress in understanding the function of linker histones and their subtypes beyond their role as merely structural chromatin components. We summarize current findings on the role of H1 in heterochromatin formation, transcriptional regulation and embryogenesis with a focus on H1 subtypes and their specific modifications.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Chromatin ; Epigenetics ; Linker Histone ; Modifications ; Subtypes
Language
english
Publication Year
2015
HGF-reported in Year
0
ISSN (print) / ISBN
1469-221X
e-ISSN
1469-3178
Journal
EMBO Reports
Quellenangaben
Volume: 16,
Issue: 11,
Pages: 1439-1453
Publisher
EMBO Press
Reviewing status
Peer reviewed
Institute(s)
Institute of Functional Epigenetics (IFE)
POF-Topic(s)
30203 - Molecular Targets and Therapies
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-502800-001
PubMed ID
26474902
Erfassungsdatum
2015-12-31