PuSH - Publication Server of Helmholtz Zentrum München: Novel types and sites of histone modifications emerge as players in the transcriptional regulation contest.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Kebede, A.F.* ; Schneider, R.* ; Daujat, S.*

Novel types and sites of histone modifications emerge as players in the transcriptional regulation contest.

FEBS J. 282, 1658-1674 (2015)

DOI

PMC

Open Access Green as soon as Postprint is submitted to ZB.

Abstract
Metrics
Extra information

N-terminal tails of histones are easily accessible outside of the nucleosomal core particle and post-translational modifications (PTMs) of these tails have been the focus of attention in the past 15-20 years. By recruiting (or excluding) specific readers, histone modifications can regulate chromatin dynamics and, by extension, DNA-dependent processes. However, until very recently, the direct impact of histone PTMs on nucleosome structure and thus on chromatin function has remained somewhat elusive. Recent findings of novel sites and types of histone PTMs located within the globular domain of histones and, in particular, on the lateral surface of the histone octamer have changed this. As a result of their structurally important location in close proximity to the DNA molecule, this new class of histone PTMs can have a direct impact on chromatin function. Depending on their precise position at the nucleosome lateral surface (e.g. near the DNA entry/exit sites or in the dyad region), histone PTMs can regulate nucleosome structure and/or stability differently. We review recent progress on how histone PTMs can influence DNA unwrapping and/or nucleosome disassembly and shed light on how these types of novel modifications contribute mechanistically to the regulation of transcriptional activity.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Dna Entry/exit Sites ; Acetylation ; Chromatin ; Dyad Axis ; Globular Domain ; Lateral Surface ; Methylation ; Nucleosome ; Transcription

ISSN (print) / ISBN 1742-464X

e-ISSN 1742-4658

Journal FEBS Journal, The

Quellenangaben Volume: 282, Issue: 9, Pages: 1658-1674

Publisher Wiley

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Functional Epigenetics (IFE)