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Open Access Green as soon as Postprint is submitted to ZB.
Epigenetics reloaded: The single-cell revolution.
Trends Cell Biol. 24, 712-723 (2014)
Mechanistically, how epigenetic states are inherited through cellular divisions remains an important open question in the chromatin field and beyond. Defining the heritability of epigenetic states and the underlying chromatin-based mechanisms within a population of cells is complicated due to cell heterogeneity combined with varying levels of stability of these states; thus, efforts must be focused toward single-cell analyses. The approaches presented here constitute the forefront of epigenetics research at the single-cell level using classic and innovative methods to dissect epigenetics mechanisms from the limited material available in a single cell. This review further outlines exciting future avenues of research to address the significance of epigenetic heterogeneity and the contributions of microfluidics technologies to single-cell isolation and analysis.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Epigenetics ; Epigenomics ; Live Cell ; Microfluidics ; Single Cell
ISSN (print) / ISBN
0962-8924
e-ISSN
1879-3088
Journal
Trends in Cell Biology
Quellenangaben
Volume: 24,
Issue: 11,
Pages: 712-723
Publisher
Elsevier
Publishing Place
Cambridge
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Functional Epigenetics (IFE)