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Open Access Green as soon as Postprint is submitted to ZB.
Synthesis and evaluation of condensed magnetic nanocrystal clusters with in vivo multispectral optoacoustic tomography for tumour targeting.
Biomaterials 91, 128-139 (2016)
Colloidal clusters of magnetic iron oxide nanocrystals (MIONs), particularly in the condensed pattern (co-CNCs), have emerged as new superstructures to improve further the performance of MIONs in applications pertaining to magnetic manipulation (drug delivery) and magnetic resonance imaging (MRI). Exploitation of the advantages they represent and their establishment in the area of nanomedicine demands a particular set of assets. The present work describes the development and evaluation of MION-based co-CNCs featuring for the first time such assets: High magnetization, as well as magnetic content and moment, high relaxivities (r2 = 400 and [Formula: see text] ) and intrinsic loss power (2.3 nH m(2) kgFe(-1)) are combined with unprecedented colloidal stability and structural integrity, stealth and drug-loading properties. The reported nanoconstructs are endowed with additional important features such as cost-effective synthesis and storage, prolonged self-life and biocompatibility. It is finally showcased with in vivo multispectral optoacoustic tomography how these properties culminate in a system suitable for targeting breast cancer and for forceful in vivo manipulation with low magnetic field gradients.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Hybrid Colloids ; Hyperthermia ; Magnetic Targeting ; Nanocrystal Clusters ; Optoacoustic Imaging ; Theranostics; Iron-oxide Nanoparticles; Mri Contrast Agents; Drug-delivery; Biomedical Applications; Protein Adsorption; Polymeric Micelles; Surface-chemistry; Cancer-therapy; Doxorubicin; Density
ISSN (print) / ISBN
0142-9612
e-ISSN
1878-5905
Journal
Biomaterials
Quellenangaben
Volume: 91,
Pages: 128-139
Publisher
Elsevier
Publishing Place
Oxford
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)