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Della Torre, S.* ; Mitro, N.* ; Fontana, R.* ; Gomaraschi, M.* ; Favari, E.* ; Recordati, C.* ; Lolli, F.* ; Quagliarini, F. ; Meda, C.* ; Ohlsson, C.* ; Crestani, M.* ; Uhlenhaut, N.H. ; Calabresi, L.* ; Maggi, A.*

An essential role for liver ERα in coupling hepatic metabolism to the reproductive cycle.

Cell Rep. 15, 360-371 (2016)
Publ. Version/Full Text Supplement DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Lipoprotein synthesis is controlled by estrogens, but the exact mechanisms underpinning this regulation and the role of the hepatic estrogen receptor α (ERα) in cholesterol physiology are unclear. Utilizing a mouse model involving selective ablation of ERα in the liver, we demonstrate that hepatic ERα couples lipid metabolism to the reproductive cycle. We show that this receptor regulates the synthesis of cholesterol transport proteins, enzymes for lipoprotein remodeling, and receptors for cholesterol uptake. Additionally, ERα is indispensable during proestrus for the generation of high-density lipoproteins efficient in eliciting cholesterol efflux from macrophages. We propose that a specific interaction with liver X receptor α (LXRα) mediates the broad effects of ERα on the hepatic lipid metabolism.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cholesterol Efflux Capacity; Estrogen-receptor; Fatty Liver; Gene-expression; Lipoprotein Metabolism; Postmenopausal Women; Binding-sites; Mouse-liver; X-receptor; A-i
Language english
Publication Year 2016
HGF-reported in Year 2016
ISSN (print) / ISBN 2211-1247
e-ISSN 2211-1247
Journal Cell Reports
Quellenangaben Volume: 15, Issue: 2, Pages: 360-371 Article Number: , Supplement: ,
Publisher Cell Press
Publishing Place Cambridge
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-501900-227
PubMed ID 27050513
DOI 10.1016/j.celrep.2016.03.019
WOS ID WOS:000374236900014
Scopus ID 84962081939
Erfassungsdatum 2016-04-14
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