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An essential role for liver ERα in coupling hepatic metabolism to the reproductive cycle.
Cell Rep. 15, 360-371 (2016)
Lipoprotein synthesis is controlled by estrogens, but the exact mechanisms underpinning this regulation and the role of the hepatic estrogen receptor α (ERα) in cholesterol physiology are unclear. Utilizing a mouse model involving selective ablation of ERα in the liver, we demonstrate that hepatic ERα couples lipid metabolism to the reproductive cycle. We show that this receptor regulates the synthesis of cholesterol transport proteins, enzymes for lipoprotein remodeling, and receptors for cholesterol uptake. Additionally, ERα is indispensable during proestrus for the generation of high-density lipoproteins efficient in eliciting cholesterol efflux from macrophages. We propose that a specific interaction with liver X receptor α (LXRα) mediates the broad effects of ERα on the hepatic lipid metabolism.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Cholesterol Efflux Capacity; Estrogen-receptor; Fatty Liver; Gene-expression; Lipoprotein Metabolism; Postmenopausal Women; Binding-sites; Mouse-liver; X-receptor; A-i
ISSN (print) / ISBN
2211-1247
e-ISSN
2211-1247
Journal
Cell Reports
Quellenangaben
Volume: 15,
Issue: 2,
Pages: 360-371
Publisher
Cell Press
Publishing Place
Cambridge
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Cancer (IDC)