PuSH - Publication Server of Helmholtz Zentrum München

Peifer, M.* ; Fernández-Cuesta, L.* ; Sos, M.L.* ; George, J.* ; Seidel, D.* ; Kasper, L.H.* ; Plenker, D.* ; Leenders, F.* ; Sun, R.* ; Zander, T.* ; Menon, R.* ; Koker, M.* ; Dahmen, I.* ; Müller, C.* ; di Cerbo, V.* ; Schildhaus, H.U.* ; Altmüller, J.* ; Baessmann, I.* ; Becker, C.* ; de Wilde, B.* ; Vandesompele, J.* ; Böhm, D.* ; Ansén, S.* ; Gabler, F.* ; Wilkening, I.* ; Heynck, S.* ; Heuckmann, J.M.* ; Lu, X.* ; Carter, S.L.* ; Cibulskis, K.* ; Banerji, S.* ; Getz, G.* ; Park, K.S.* ; Rauh, D.* ; Grütter, C.* ; Fischer, M.* ; Pasqualucci, L.* ; Wright, G.* ; Wainer, Z.* ; Russell, P.* ; Petersen, I.* ; Chen, Y.* ; Stoelben, E.* ; Ludwig, C.* ; Schnabel, P.A.* ; Hoffmann, H.* ; Muley, T.* ; Brockmann, M.M.* ; Engel-Riedel, W.* ; Muscarella, L.A.* ; Fazio, V.M.* ; Groen, H.J.M.* ; Timens, W.* ; Sietsma, H.* ; Thunnissen, E.* ; Smit, E.* ; Heideman, D.A.* ; Snijders, P.J.* ; Cappuzzo, F.* ; Ligorio, C.* ; Damiani, S.* ; Field, J.* ; Solberg, S.* ; Brustugun, O.T.* ; Lund-Iversen, M.* ; Sänger, J.* ; Clement, J.H.* ; Soltermann, A.* ; Moch, H.* ; Weder, W.* ; Solomon, B.* ; Soria, J.C.* ; Validire, P.* ; Besse, B.* ; Brambilla, E.* ; Brambilla, C.* ; Lantuejoul, S.* ; Lorimier, P.* ; Schneider, P.M.* ; Hallek, M.* ; Pao, W.* ; Meyerson, M.* ; Sage, J.* ; Shendure, J.* ; Schneider, R.* ; Büttner, R.* ; Wolf, J.* ; Nürnberg, P.* ; Perner, S.* ; Heukamp, L.C.* ; Brindle, P.K.* ; Haas, S.* ; Thomas, R.K.*

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.

Nat. Genet. 44, 1104-1110 (2012)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis. We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and found an extremely high mutation rate of 7.4±1 protein-changing mutations per million base pairs. Therefore, we conducted integrated analyses of the various data sets to identify pathogenetically relevant mutated genes. In all cases, we found evidence for inactivation of TP53 and RB1 and identified recurrent mutations in the CREBBP, EP300 and MLL genes that encode histone modifiers. Furthermore, we observed mutations in PTEN, SLIT2 and EPHA7, as well as focal amplifications of the FGFR1 tyrosine kinase gene. Finally, we detected many of the alterations found in humans in SCLC tumors from Tp53 and Rb1 double knockout mice. Our study implicates histone modification as a major feature of SCLC, reveals potentially therapeutically tractable genomic alterations and provides a generalizable framework for the identification of biologically relevant genes in the context of high mutational background.
Altmetric
Additional Metrics?
[➜Log in]
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 44, Issue: 10, Pages: 1104-1110 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Functional Epigenetics (IFE)