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Histone modifiers in cancer: Friends or foes?
Genes Cancer 2, 631-647 (2011)
Covalent modifications of histones can regulate all DNA-dependent processes. In the last few years, it has become more and more evident that histone modifications are key players in the regulation of chromatin states and dynamics as well as in gene expression. Therefore, histone modifications and the enzymatic machineries that set them are crucial regulators that can control cellular proliferation, differentiation, plasticity, and malignancy processes. This review discusses the biology and biochemistry of covalent histone posttranslational modifications (PTMs) and evaluates the dual role of their modifiers in cancer: as oncogenes that can initiate and amplify tumorigenesis or as tumor suppressors.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Acetylation ; Cancer ; Chromatin ; Histone Modifications ; Methylation ; Phosphorylation
ISSN (print) / ISBN
1947-6019
e-ISSN
1947-6027
Journal
Genes and Cancer
Quellenangaben
Volume: 2,
Issue: 6,
Pages: 631-647
Publisher
Sage
Publishing Place
Thousand Oaks, Calif.
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Functional Epigenetics (IFE)