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Open Access Green as soon as Postprint is submitted to ZB.
Arginine methylation of the B cell antigen receptor promotes differentiation.
J. Exp. Med. 207, 711-719 (2010)
Signals processed through the B cell antigen receptor (BCR) control both the proliferation and differentiation of B lymphocytes. How these different signaling modes are established at the BCR is poorly understood. We show that a conserved arginine in the tail sequence of the Igalpha subunit of the BCR is methylated by the protein arginine methyltransferase 1. This modification negatively regulates the calcium and PI-3 kinase pathways of the BCR while promoting signals leading to B cell differentiation. Thus, Igalpha arginine methylation can play an important role in specifying the outcome of BCR signaling.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0022-1007
e-ISSN
1540-9538
Journal
Journal of Experimental Medicine
Quellenangaben
Volume: 207,
Issue: 4,
Pages: 711-719
Publisher
Rockefeller University Press
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Functional Epigenetics (IFE)