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Open Access Green as soon as Postprint is submitted to ZB.
What an epigenome remembers.
Bioessays 32, 659-668 (2010)
During mammalian development, maintenance of cell fate through mitotic divisions require faithful replication not only of the DNA but also of a particular epigenetic state. Germline cells have the capacity of erasing this epigenetic memory at crucial times during development, thereby resetting their epigenome. Certain marks, however, appear to escape this reprogramming, which allows their transmission to the offspring and potentially guarantees transgenerational epigenetic inheritance. Here we discuss the molecular requirements for faithful transmission of epigenetic information and our current knowledge about the transmission of epigenetic information through generations.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0265-9247
e-ISSN
1521-1878
Journal
BioEssays
Quellenangaben
Volume: 32,
Issue: 8,
Pages: 659-668
Publisher
Wiley
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Functional Epigenetics (IFE)