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Casciati, A.* ; Dobos, K.* ; Antonelli, F.* ; Benedek, A.* ; Kempf, S.J. ; Bellés, M.* ; Balogh, A.* ; Tanori, M.* ; Heredia, L.* ; Atkinson, M.J. ; von Toerne, C. ; Azimzadeh, O. ; Saran, A.* ; Sáfrány, G.* ; Benotmane, M.A.* ; Linares-Vidal, M.V.* ; Tapio, S. ; Lumniczky, K.* ; Pazzaglia, S.*

Age-related effects of X-ray irradiation on mouse hippocampus.

Oncotarget 7, 28040-28058 (2016)
Publ. Version/Full Text Research data DOI PMC
Creative Commons Lizenzvertrag
Therapeutic irradiation of pediatric and adult patients can profoundly affect adult neurogenesis, and cognitive impairment manifests as a deficit in hippocampal-dependent functions. Age plays a major role in susceptibility to radiation, and younger children are at higher risk of cognitive decay when compared to adults. Cranial irradiation affects hippocampal neurogenesis by induction of DNA damage in neural progenitors, through the disruption of the neurogenic microenvironment, and defective integration of newborn neurons into the neuronal network. Our goal here was to assess cellular and molecular alterations induced by cranial X-ray exposure to low/moderate doses (0.1 and 2 Gy) in the hippocampus of mice irradiated at the postnatal ages of day 10 or week 10, as well as the dependency of these phenomena on age at irradiation. To this aim, changes in the cellular composition of the dentate gyrus, mitochondrial functionality, proteomic profile in the hippocampus, as well as cognitive performance were evaluated by a multidisciplinary approach. Our results suggest the induction of specific alterations in hippocampal neurogenesis, microvascular density and mitochondrial functions, depending on age at irradiation. A better understanding of how irradiation impairs hippocampal neurogenesis at low and moderate doses is crucial to minimize adverse effects of therapeutic irradiation, contributing also to radiation safety regulations.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Cognitive Effects ; Hippocampal Neurogenesis ; Mitochondria ; Proteomics ; Radiation; Induced Cognitive Impairment; Neural Stem-cells; Adult Neurogenesis; Ionizing-radiation; Cranial Irradiation; Developing Brain; Functional Consequences; Oxidative Stress; Progenitor Cells; Mitochondrial
ISSN (print) / ISBN 1949-2553
e-ISSN 1949-2553
Journal OncoTarget
Quellenangaben Volume: 7, Issue: 19, Pages: 28040-28058 Article Number: , Supplement: ,
Publisher Impact Journals LLC
Publishing Place Albany
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Radiation Biology (ISB)
CF Metabolomics & Proteomics (CF-MPC)