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Open Access Green as soon as Postprint is submitted to ZB.
Protein N-methyltransferase assays in the study of gene transcription.
Methods 26, 226-232 (2002)
Protein N-methylation has recently emerged as a major mechanism involved in regulating gene transcription and epigenetic inheritance. Transcriptional coactivators and corepressors have both been shown to associate with protein N-methyltransferases. These enzymes methylate arginine or lysine residues within histones as well as other proteins, such as transcription factors. Here, we discuss the recent advances in our understanding of protein methylation and its involvement in gene expression. Protocols are presented for studying transcriptionally relevant protein methylation.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
1046-2023
e-ISSN
1095-9130
Journal
Methods
Quellenangaben
Volume: 26,
Issue: 3,
Pages: 226-232
Publisher
Elsevier
Publishing Place
Amsterdam [u.a.]
Reviewing status
Peer reviewed
Institute(s)
Institute of Functional Epigenetics (IFE)