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Open Access Green as soon as Postprint is submitted to ZB.
Unsafe SETs: Histone lysine methyltransferases and cancer.
Trends Biochem. Sci. 27, 396-402 (2002)
Enzymes that covalently modify histones control many cellular processes by affecting gene expression. A new class of these enzymes is the histone lysine methyltransferase family, whose catalytic activity lies within a conserved domain, the SET domain. This article surveys the evidence for a connection between SET-domain-containing proteins and cancer. It proposes that deregulation of SET-domain function has an important role in carcinogenesis.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0376-5067
e-ISSN
0968-0004
Quellenangaben
Volume: 27,
Issue: 8,
Pages: 396-402
Publisher
Elsevier
Publishing Place
Cambridge
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Functional Epigenetics (IFE)