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Schneider, R.* ; Bannister, A.J.* ; Kouzarides, T.*

Unsafe SETs: Histone lysine methyltransferases and cancer.

Trends Biochem. Sci. 27, 396-402 (2002)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Enzymes that covalently modify histones control many cellular processes by affecting gene expression. A new class of these enzymes is the histone lysine methyltransferase family, whose catalytic activity lies within a conserved domain, the SET domain. This article surveys the evidence for a connection between SET-domain-containing proteins and cancer. It proposes that deregulation of SET-domain function has an important role in carcinogenesis.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2002
HGF-reported in Year 0
ISSN (print) / ISBN 0376-5067
e-ISSN 0968-0004
Journal Trends in Biochemical Sciences : TIBS
Quellenangaben Volume: 27, Issue: 8, Pages: 396-402 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Cambridge
Reviewing status Peer reviewed
Institute(s) Institute of Functional Epigenetics (IFE)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502800-001
PubMed ID 12151224
DOI 10.1016/S0968-0004(02)02141-2
Erfassungsdatum 2002-12-31
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