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The expression of the Escherichia coli fis gene is strongly dependent on the superhelical density of DNA.
Mol. Microbiol. 38, 167-175 (2000)
The Escherichia coli DNA architectural protein FIS is a pleiotropic regulator, which couples the cellular physiology with transitions in the superhelical density of bacterial DNA. Recently, we have shown that this effect is in part mediated via DNA gyrase, the major cellular topoisomerase responsible for the elevation of negative supercoiling. Here, we demonstrate that, in turn, the expression of the fis gene strongly responds to alterations in the topology of DNA in vivo, being maximal at high levels of negative supercoiling. Any deviations from these optimal levels decrease fis promoter activity. This strict dependence of fis expression on the superhelical density suggests that fis may be involved in 'fine-tuning' the homeostatic control mechanism of DNA supercoiling in E. coli.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
2000
HGF-reported in Year
0
ISSN (print) / ISBN
0950-382x
e-ISSN
1365-2958
Journal
Molecular Microbiology
Quellenangaben
Volume: 38,
Issue: 1,
Pages: 167-175
Publisher
Wiley
Reviewing status
Peer reviewed
Institute(s)
Institute of Functional Epigenetics (IFE)
POF-Topic(s)
30203 - Molecular Targets and Therapies
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-502800-001
PubMed ID
11029698
Erfassungsdatum
2000-12-31