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Open Access Green as soon as Postprint is submitted to ZB.
How cells build totipotency and pluripotency: Nuclear, chromatin and transcriptional architecture.
Curr. Opin. Cell Biol. 34, 9-15 (2015)
Totipotent and pluripotent cells display different degrees of cellular plasticity. After fertilization, embryonic cells transit naturally from a totipotent to a pluripotent state. Major changes in nuclear architecture, chromatin mobility and gene expression occur during this transition. In particular, nuclear architecture has recently emerged as a potential regulator of heterochromatin formation in the early embryo. Future research should address whether a causal, functional link between nuclear organization and gene regulation is a general theme during reprogramming and the formation of pluripotent cells.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
2015
HGF-reported in Year
0
ISSN (print) / ISBN
0955-0674
e-ISSN
1879-0410
Journal
Current Opinion in Cell Biology
Quellenangaben
Volume: 34,
Pages: 9-15
Publisher
Elsevier
Publishing Place
Kidlington
Reviewing status
Peer reviewed
Institute(s)
Institute of Epigenetics and Stem Cells (IES)
POF-Topic(s)
30204 - Cell Programming and Repair
Research field(s)
Stem Cell and Neuroscience
PSP Element(s)
G-506200-001
PubMed ID
25935759
Erfassungsdatum
2015-12-31