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Dang-Nguyen, T.Q.* ; Torres-Padilla, M.E.*

How cells build totipotency and pluripotency: Nuclear, chromatin and transcriptional architecture.

Curr. Opin. Cell Biol. 34, 9-15 (2015)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Totipotent and pluripotent cells display different degrees of cellular plasticity. After fertilization, embryonic cells transit naturally from a totipotent to a pluripotent state. Major changes in nuclear architecture, chromatin mobility and gene expression occur during this transition. In particular, nuclear architecture has recently emerged as a potential regulator of heterochromatin formation in the early embryo. Future research should address whether a causal, functional link between nuclear organization and gene regulation is a general theme during reprogramming and the formation of pluripotent cells.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 0955-0674
e-ISSN 1879-0410
Quellenangaben Volume: 34, Issue: , Pages: 9-15 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Kidlington
Non-patent literature Publications
Reviewing status Peer reviewed