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Open Access Green as soon as Postprint is submitted to ZB.
Chromatin dynamics in the regulation of cell fate allocation during early embryogenesis.
Nat. Rev. Mol. Cell Biol. 15, 723-734 (2014)
Following fertilization, gametes undergo epigenetic reprogramming in order to revert to a totipotent state. How embryonic cells subsequently acquire their fate and the role of chromatin dynamics in this process are unknown. Genetic and experimental embryology approaches have identified some of the players and morphological changes that are involved in early mammalian development, but the exact events underlying cell fate allocation in single embryonic cells have remained elusive. Experimental and technological advances have recently provided novel insights into chromatin dynamics and nuclear architecture in single cells; these insights have reshaped our understanding of the mechanisms underlying cell fate allocation and plasticity in early mammalian development.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
1471-0072
e-ISSN
1471-0080
Quellenangaben
Volume: 15,
Issue: 11,
Pages: 723-734
Publisher
Nature Publishing Group
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epigenetics and Stem Cells (IES)