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Open Access Green as soon as Postprint is submitted to ZB.
LINEing germ and embryonic stem cells' silencing of retrotransposons.
Genes Dev. 28, 1381-1383 (2014)
Almost half of our genome is occupied by transposable elements. Although most of them are inactive, one type of non-long terminal repeat (LTR) retrotransposon, long interspersed nuclear element 1 (LINE1), is capable of retrotransposition. Two studies in this issue, Pezic and colleagues (pp. 1410-1428) and Castro-Diaz and colleagues (pp. 1397-1409), provide novel insight into the regulation of LINE1s in human embryonic stem cells and mouse germ cells and shed new light on the conservation of complex mechanisms to ensure silencing of transposable elements in mammals.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Dna Methylation ; Kap1 ; Line1 ; Evolution ; Pirna ; Transposon
ISSN (print) / ISBN
0890-9369
e-ISSN
1549-5477
Journal
Genes and Development
Quellenangaben
Volume: 28,
Issue: 13,
Pages: 1381-1383
Publisher
Cold Spring Harbor Laboratory Press
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epigenetics and Stem Cells (IES)