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Open Access Green as soon as Postprint is submitted to ZB.
Transcription factor heterogeneity in pluripotent stem cells: A stochastic advantage.
Development 141, 2173-2181 (2014)
When pluripotent cells are exposed to a uniform culture environment they routinely display heterogeneous gene expression. Aspects of this heterogeneity, such as Nanog expression, are linked to differences in the propensity of individual cells to either self-renew or commit towards differentiation. Recent findings have provided new insight into the underlying causes of this heterogeneity, which we summarise here using Nanog, a key regulator of pluripotency, as a model gene. We discuss the role of transcription factor heterogeneity in facilitating the intrinsically dynamic and stochastic nature of the pluripotency network, which in turn provides a potential benefit to a population of cells that needs to balance cell fate decisions.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Embryonic Stem Cell (esc) ; Epiblast ; Heterogeneity ; Monoallelic ; Pluripotency ; Transcription
ISSN (print) / ISBN
0950-1991
e-ISSN
1477-9129
Quellenangaben
Volume: 141,
Issue: 11,
Pages: 2173-2181
Publisher
Company of Biologists
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epigenetics and Stem Cells (IES)