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Open Access Green as soon as Postprint is submitted to ZB.
Restrictions in time and space - new insights into generation of specific neuronal subtypes in the adult mammalian brain.
Eur. J. Neurosci. 33, 1045-1054 (2011)
Key questions in regard to neuronal repair strategies are which cells are best suited to regenerate specific neuronal subtypes and how much of a neuronal circuit needs to persist in order to allow its functional repair. Here we discuss recent findings in the field of adult neurogenesis, which shed new light on these questions. Neural stem cells in the adult brain generate very distinct types of neurons depending on their regional and temporal specification. Moreover, distinct brain regions differ in the mode of neuron addition in adult neurogenesis, suggesting that different brain circuits may be able to cope differently with the incorporation of new neurons. These new insights are then considered in regard to the choice of cells with the appropriate region-specific identity for repair strategies.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
neural stem cells; neurogenesis; neuronal repair; neuronal subtype specification; olfactory bulk; transcription factors
ISSN (print) / ISBN
0953-816X
e-ISSN
1460-9568
Journal
European Journal of Neuroscience
Quellenangaben
Volume: 33,
Issue: 6,
Pages: 1045-1054
Publisher
Wiley
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)