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How mammals pack their sperm: A variant matter.
Genes Dev. 27, 1635-1639 (2013)
Producing competent gametes is essential for transmitting genetic information throughout generations. Spermatogenesis is a unique example of rearrangements of genome packaging to ensure fertilization. After meiosis, spermatids undergo drastic morphological changes, perhaps the most dramatic ones occurring in their nuclei, including the transition into a protamine-packaged genome. In this issue of Genes & Development, Montellier and colleagues (pp. 1680-1692) shed new light on the molecular mechanisms regulating this transition by ascribing for the first time a function to a histone variant, TH2B, in the regulation of this process.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Brdt ; H2az ; Histone Eviction ; Male Contraception ; Male Infertility ; Reprogramming ; Sex Chromosome Inactivation
Language
english
Publication Year
2013
HGF-reported in Year
0
ISSN (print) / ISBN
0890-9369
e-ISSN
1549-5477
Journal
Genes and Development
Quellenangaben
Volume: 27,
Issue: 15,
Pages: 1635-1639
Publisher
Cold Spring Harbor Laboratory Press
Reviewing status
Peer reviewed
Institute(s)
Institute of Epigenetics and Stem Cells (IES)
POF-Topic(s)
30204 - Cell Programming and Repair
Research field(s)
Stem Cell and Neuroscience
PSP Element(s)
G-506200-001
PubMed ID
23913918
Erfassungsdatum
2013-12-31