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Open Access Green as soon as Postprint is submitted to ZB.
Towards an understanding of the regulatory mechanisms of totipotency.
Curr. Opin. Genet. Dev. 23, 512-518 (2013)
The 21st century started with an important discovery that a pluripotent stem cell can be induced from differentiated cells by 'simply' introducing a few transcription factors. Because pluripotent embryonic stem cells can be stably maintained in culture and also induced, the mechanisms as to how cells maintain and acquire pluripotency have been extensively interrogated. In contrast, how cells maintain or acquire totipotency and the cell potency that exists in the zygote are still poorly understood. To address this question, it is necessary to capture the features that reside in totipotent cells. Here, we review recent results, which shed light on the unique epigenetic state in totipotent cells, and discuss how totipotency is regulated before finding its way towards pluripotency.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0959-437X
e-ISSN
1879-0380
Quellenangaben
Volume: 23,
Issue: 5,
Pages: 512-518
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epigenetics and Stem Cells (IES)