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Yaroshenko, A.* ; Pritzke, T. ; Koschlig, M. ; Kamgari, N. ; Willer, K.* ; Gromann, L.* ; Auweter, S.* ; Hellbach, K.* ; Reiser, M.* ; Eickelberg, O. ; Pfeiffer, F.* ; Hilgendorff, A.

Visualization of neonatal lung injury associated with mechanical ventilation using X-ray dark-field radiography.

Sci. Rep. 6:24269 (2016)

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Mechanical ventilation (MV) and supplementation of oxygen-enriched gas, often needed in postnatal resuscitation procedures, are known to be main risk factors for impaired pulmonary development in the preterm and term neonates. Unfortunately, current imaging modalities lack in sensitivity for the detection of early stage lung injury. The present study reports a new imaging approach for diagnosis and staging of early lung injury induced by MV and hyperoxia in neonatal mice. The imaging method is based on the Talbot-Lau x-ray grating interferometry that makes it possible to quantify the x-ray small-angle scattering on the air-tissue interfaces. This so-called dark-field signal revealed increasing loss of x-ray small-angle scattering when comparing images of neonatal mice undergoing hyperoxia and MV-O2 with animals kept at room air. The changes in the dark field correlated well with histologic findings and provided superior differentiation than conventional x-ray imaging and lung function testing. The results suggest that x-ray dark-field radiography is a sensitive tool for assessing structural changes in the developing lung. In the future, with further technical developments x-ray dark-field imaging could be an important tool for earlier diagnosis and sensitive monitoring of lung injury in neonates requiring postnatal oxygen or ventilator therapy.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Developing Bronchopulmonary Dysplasia; Phase-contrast; Computed-tomography; Pulmonary-emphysema; Preterm Infants; Function Tests; Disease; Diagnosis; Vivo; Ct

ISSN (print) / ISBN 2045-2322

e-ISSN 2045-2322

Journal Scientific Reports

Quellenangaben Volume: 6, Article Number: 24269

Publisher Nature Publishing Group

Publishing Place London

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Lung Health and Immunity (LHI)