PuSH - Publication Server of Helmholtz Zentrum München: Dietary triglycerides as signaling molecules that influence reward and motivation.

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Berland, C. ; Cansell, C.* ; Hnasko, T.S.* ; Magnan, C.* ; Luquet, S.*

Dietary triglycerides as signaling molecules that influence reward and motivation.

Curr. Opin. Behav. Sci. 9, 126-135 (2016)

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The reinforcing and motivational aspects of food are tied to the release of the dopamine in the mesolimbic system (ML). Free fatty acids from triglyceride (TG)-rich particles are released upon action of TG-lipases found at high levels in peripheral oxidative tissue (muscle, heart), but also in the ML. This suggests that local TG-hydrolysis in the ML might regulate food seeking and reward. Indeed, evidence now suggests that dietary TG directly target the ML to regulate amphetamine-induced locomotion and reward seeking behavior. Though the cellular mechanisms of TG action are unresolved, TG act in part through ML lipoprotein lipase, upstream of dopamine 2 receptor (D2R), and show desensitization in conditions of chronically elevated plasma TG as occur in obesity. TG sensing in the ML therefore represents a new mechanism by which chronic consumption of dietary fat might lead to adaptations in the ML and dysregulated feeding behaviors.

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