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Identification of GPR83 as the receptor for the neuroendocrine peptide PEN.
Sci. Signal. 9:ra43 (2016)
PEN is an abundant peptide in the brain that has been implicated in the regulation of feeding. We identified a receptor for PEN in mouse hypothalamus and Neuro2A cells. PEN bound to and activated GPR83, a G protein (heterotrimeric guanine nucleotide)-binding protein)-coupled receptor (GPCR). Reduction of GPR83 expression in mouse brain and Neuro2A cells reduced PEN binding and signaling, consistent with GPR83 functioning as the major receptor for PEN. In some brain regions, GPR83 colocalized with GPR171, a GPCR that binds the neuropeptide bigLEN, another neuropeptide that is involved in feeding and is generated from the same precursor protein as is PEN. Coexpression of these two receptors in cell lines altered the signaling properties of each receptor, suggesting a functional interaction. Our data established PEN as a neuropeptide that binds GPR83 and suggested that these two ligand-receptor systems-PEN-GPR83 and bigLEN-GPR171-may be functionally coupled in the regulation of feeding.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Protein-coupled Receptor; Glucocorticoid-induced Receptor; Regulatory T-cells; Jp05 Messenger-rna; Mouse-brain; Rat-brain; In-vivo; Expression; Prosaas; Mice
Language
english
Publication Year
2016
HGF-reported in Year
2016
ISSN (print) / ISBN
1945-0877
e-ISSN
1937-9145
Journal
Science Signaling
Quellenangaben
Volume: 9,
Issue: 425,
Article Number: ra43
Publisher
American Association for the Advancement of Science (AAAS)
Publishing Place
Washington
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Obesity (IDO)
POF-Topic(s)
30201 - Metabolic Health
90000 - German Center for Diabetes Research
90000 - German Center for Diabetes Research
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-502200-001
G-501900-221
G-501900-221
WOS ID
WOS:000374829200004
Scopus ID
84964787407
PubMed ID
27117253
Erfassungsdatum
2016-05-09