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Dopamine depletion reduces food-related reward activity independent of BMI.
Neuropsychopharmacology 41, 1551-1559 (2016)
Publ. Version/Full Text
DOI
Reward sensitivity and possible alterations in the dopaminergic-reward system are associated with obesity. We therefore aimed to investigate the influence of dopamine depletion on food-reward processing. We investigated 34 female subjects in a randomized placebo controlled, within-subject design (body mass index (BMI) = 27.0 kg/m(2) +/- 4.79 SD; age = 28 years +/- 4.97 SD) using an acute phenylalanine/tyrosine depletion drink representing dopamine depletion and a balanced amino acid drink as the control condition. Brain activity was measured with functional magnetic resonance imaging during a 'wanting' and 'liking' rating of food items. Eating behavior-related traits and states were assessed on the basis of questionnaires. Dopamine depletion resulted in reduced activation in the striatum and higher activation in the superior frontal gyms independent of BMI. Brain activity during the wanting task activated a more distributed network than during the liking task This network included gustatory, memory, visual, reward, and frontal regions. An interaction effect of dopamine depletion and the wanting/liking task was observed in the hippocampus. The interaction with the covariate BMI was significant in motor and control regions but not in the striatum. Our results support the notion of altered brain activity in the reward and prefrontal network with blunted dopaminergic action during food-reward processing. This effect is, however, independent of BMI, which contradicts the reward-deficiency hypothesis. This hints to the hypothesis suggesting a different or more complex mechanism underlying the dopaminergic reward function in obesity.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Acute Tyrosine/phenylalanine Depletion; Acute Phenylalanine/tyrosine Depletion; Acute Tyrosine Depletion; Smoking-related Cues; Precursor Depletion; Catecholamine Synthesis; Memory Performance; Future-directions; Brain Dopamine; Wanting Food
ISSN (print) / ISBN
0893-133X
e-ISSN
1470-634X
Journal
Neuropsychopharmacology
Quellenangaben
Volume: 41,
Issue: 6,
Pages: 1551-1559
Publisher
Nature Publishing Group
Publishing Place
London
Non-patent literature
Publications
Reviewing status
Peer reviewed