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Karapiperis, C.* ; Kempf, S.J. ; Quintens, R.* ; Azimzadeh, O. ; Vidal, V.L.* ; Pazzaglia, S.* ; Bazyka, D.* ; Mastroberardino, P.G.* ; Scouras, Z.G.* ; Tapio, S. ; Benotmane, M.A.* ; Ouzounis, C.A.*

Brain Radiation Information Data Exchange (BRIDE): Integration of experimental data from low-dose ionising radiation research for pathway discovery.

BMC Bioinformatics 17:212 (2016)

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BACKGROUND: The underlying molecular processes representing stress responses to low-dose ionising radiation (LDIR) in mammals are just beginning to be understood. In particular, LDIR effects on the brain and their possible association with neurodegenerative disease are currently being explored using omics technologies. RESULTS: We describe a light-weight approach for the storage, analysis and distribution of relevant LDIR omics datasets. The data integration platform, called BRIDE, contains information from the literature as well as experimental information from transcriptomics and proteomics studies. It deploys a hybrid, distributed solution using both local storage and cloud technology. CONCLUSIONS: BRIDE can act as a knowledge broker for LDIR researchers, to facilitate molecular research on the systems biology of LDIR response in mammals. Its flexible design can capture a range of experimental information for genomics, epigenomics, transcriptomics, and proteomics. The data collection is available at: bride.azurewebsites.net .

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Brain Research ; Data Integration ; Low-dose Ionising Radiation ; Omics Technologies ; Systems Biology; Synaptic Plasticity; Proteomic Analysis; Endothelial-cells; Cognitive Defects; Irradiated Mice; Gene-expression; Body Exposure; Cancer-risks; Bioinformatics; Challenges

ISSN (print) / ISBN 1471-2105

e-ISSN 1471-2105

Journal BMC Bioinformatics

Quellenangaben Volume: 17, Issue: 1, Article Number: 212

Publisher BioMed Central

Publishing Place London

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Radiation Biology (ISB)