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Open Access Green as soon as Postprint is submitted to ZB.
Flattened circadian cortisol rhythm in type 2 diabetes.
Exp. Clin. Endocrinol. Diabet. 119, 573-575 (2011)
While altered cortisol concentrations have been observed in subjects with type 2 diabetes their circadian cortisol profile is unknown. Using a cross-sectional design, we studied 63 ambulatory individuals with type 2 diabetes and 916 non-diabetic control subjects of the Cooperative Research in the Region of Augsburg (KORA)-F3 study. Circadian cortisol profiles were derived from saliva cortisol concentrations, determined on a regular weekday upon wake-up (F0), as well as ½ h (F½), 8 (F8) and 14 h (F14) after wake-up. Diabetic subjects exhibited a flattened circadian cortisol profile (rm-ANOVA: F[3,654]=3.41, p=0.02), with lower morning and higher afternoon and evening cortisol concentrations. observed a flattened circadian cortisol rhythm in subjects with type 2 diabetes, providing evidence for a specific HPA system dysfunction.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
glucocorticoids; hypothalamic-pituitary-adrenal system; circadian rhythm
ISSN (print) / ISBN
0947-7349
e-ISSN
1439-3646
Quellenangaben
Volume: 119,
Issue: 9,
Pages: 573-575
Publisher
Thieme
Publishing Place
Stuttgart
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)