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Lanzinger, S. ; Schneider, A.E. ; Breitner-Busch, S. ; Stafoggia, M.* ; Erzen, I.* ; Dostal, M.* ; Pastorkova, A.* ; Bastian, S.* ; Cyrys, J. ; Zscheppang, A.* ; Kolodnitska, T.* ; Peters, A.

Ultrafine and fine particles and hospital admissions in Central Europe: Results from the UFIREG study.

Am. J. Respir. Crit. Care Med. 194, 1233-1241 (2016)
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RATIONALE: Evidence on short-term effects of ultrafine particles (UFP) on health is still inconsistent and few multi-center studies have been conducted so far especially in Europe. OBJECTIVES: Within the UFIREG project, we investigated the short-term effects of UFP and fine particulate matter <2.5 µm (PM2.5) on daily cause-specific hospital admissions in five Central and Eastern European cities using harmonized protocols for measurements and analyses. METHODS: Daily counts of cause-specific hospital admissions were obtained for Augsburg and Dresden (Germany) 2011-2012, Chernivtsi (Ukraine) 2013-March 2014, Ljubljana (Slovenia) and Prague (Czech Republic) 2012-2013 focusing on cardiovascular and respiratory diseases. Air pollution and meteorological data were measured at fixed monitoring sites in all cities. We analyzed city-specific associations using confounder-adjusted Poisson regression models and pooled the city-specific effect estimates using meta-analyses methods. MAIN RESULTS: A 2,750 particles/cm3 increase (average interquartile range (IQR) across all cities) in the 6-day average of UFP indicated a delayed and prolonged increase in the pooled relative risk of respiratory hospital admissions (3.4% [95%-confidence interval:-1.7%;8.8%]). We also found increases in the pooled relative risk of cardiovascular (exposure average of lag 2-5: 1.8% [0.1%;3.4%]) and respiratory (6-day average exposure: 7.5% [4.9%;10.2%]) admissions per 12.4 µg/m3 increase (average IQR) in PM2.5. CONCLUSIONS: Our findings indicated delayed and prolonged effects of UFP exposure on respiratory hospital admissions in Central and Eastern Europe. Cardiovascular and respiratory hospital admissions increased in association with an increase in PM2.5. Further multi-center studies are needed using harmonized UFP measurements to draw definite conclusions on health effects of UFP.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Particulate Matter ; Ultrafine Particles ; Cardiovascular ; Hospital Admissions ; Respiratory; Particulate Air-pollution; American-heart-association; Cardiovascular-disease; Number Concentrations; Respiratory-diseases; Time-series; Size; Mortality; Metaanalysis; Matter
Language english
Publication Year 2016
HGF-reported in Year 2016
ISSN (print) / ISBN 1073-449X
e-ISSN 1535-4970
Journal American Journal of Respiratory and Critical Care Medicine
Quellenangaben Volume: 194, Issue: 10, Pages: 1233-1241 Article Number: , Supplement: ,
Publisher American Thoracic Society
Publishing Place New York
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-001
G-504000-004
DOI 10.1164/rccm.201510-2042OC
WOS ID WOS:000388250800012
Scopus ID 84998962671
PubMed ID 27224452
Erfassungsdatum 2016-05-31
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