PuSH - Publication Server of Helmholtz Zentrum München: First investigation of two obesity-related loci (TMEM18, FTO) concerning their association with educational level as well as income: The MONICA/KORA study.

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Holzapfel, C. ; Grallert, H. ; Baumert, J.J. ; Thorand, B. ; Döring, A. ; Wichmann, H.-E. ; Hauner, H.* ; Illig, T. ; Mielck, A.

First investigation of two obesity-related loci (TMEM18, FTO) concerning their association with educational level as well as income: The MONICA/KORA study.

J. Epidemiol. Community Health 65, 174-176 (2011)

DOI

PMC

Open Access Green as soon as Postprint is submitted to ZB.

Abstract
Metrics
Extra information

Background Strong evidence exists for an association between socioeconomic status and body mass index (BMI) as well as between genetic variants and BMI. The association of genetic variants with socioeconomic status has not yet been investigated. The aim of this study was to investigate two obesity-related loci-the transmembrane 18 (TMEM18) and the fat mass and obesity-associated (FTO) gene-for their association with educational level and per capita income, and to test whether the detected genotype-BMI association is mediated by these social factors. Methods 12 425 adults from a large population-based study were genotyped for the polymorphism rs6548238 near TMEM18 and rs9935401 within the FTO gene. Data on educational level and per capita income were based on standardised questionnaires. Results High educational level and high per capita income were significantly associated with decreased BMI (-1.503 kg/m(2), p<0.0001/-0.820 kg/m(2), p<0.0001). Neither the polymorphism rs6548238 nor rs9935401 nor their combination were significantly associated with educational level (p=0.773/p=0.827/p=0.755) or income (p=0.751/p=0.991/p=0.820). Adjustment for social factors did not change the association between rs6548238 or rs9935401 and BMI. Conclusions As far as the authors know, this is the first study to investigate the association between polymorphisms and socioeconomic status. The polymorphisms rs6548238 and rs9935401 showed no association with educational level or income.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

3.043

1.655