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Mitschke, S.* ; Welthagen, W.* ; Zimmermann, R.

Comprehensive gas chromatography -time-of-flight mass spectrometry using soft and selective photoionization techniques.

Anal. Chem. 78, 6364-6375 (2006)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The hyphenation of gas chromatography and mass spectrometry (GC/MS) revolutionized organic analysis. In GC/ MS coupling, usually electron impact ionization is applied, and molecules are identified by their fragment pattern. Although mass spectrometry in principle is a separation method, it is used predominantly as a spectrometric technique. However, if soft (i.e., fragmentation-free) ionization techniques are applied, the inherent separation character of MS is emphasized, which has similarities to a GC boiling point separation. By combining polar column GC separation and fast soft ionization time-of-flight mass spectrometry technology, a comprehensive separation of complex petrochemical samples can be obtained ( GC x MS approach). Compounds of comparable physical-chemical properties are characteristically grouped together in a two-dimensional retention time-m/z representation. This resembles the separation characteristics of comprehensive two-dimensional gas chromatography ( GC x GC) and, thus, represents a novel multidimensional separation approach. In this work, a gas chromatograph equipped with a polar separation column was coupled to a home-built laser ionization time-of-flight mass spectrometer. Laser-based, single-photon ionization was used for universal soft ionization and resonance-enhanced multiphoton ionization for selective ionization of aromatic compounds. A novel capillary-jet inlet system was used for the coupling. Multidimensional comprehensive analysis of complex petrochemical hydrocarbon samples using gas chromatography coupled to mass spectrometry with soft and selective photo ionization sources is first demonstrated.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Comprehensive gas chromatography; time-of-flight mass spectrometry; photoionization; capillary-jet inlet; complex petrochemical hydrocarbon samples
ISSN (print) / ISBN 0003-2700
e-ISSN 1520-6882
Journal Analytical Chemistry
Quellenangaben Volume: 78, Issue: 18, Pages: 6364-6375 Article Number: , Supplement: ,
Publisher American Chemical Society (ACS)
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Ecological Chemistry (IOEC)
Cooperation Group Comprehensive Molecular Analytics (CMA)