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A restricted period for formation of outer subventricular zone defined by Cdh1 and Trnp1 levels.
Nat. Commun. 7:11812 (2016)
The outer subventricular zone (OSVZ) is a germinal layer playing key roles in the development of the neocortex, with particular relevance in gyrencephalic species such as human and ferret, where it contains abundant basal radial glia cells (bRGCs) that promote cortical expansion. Here we identify a brief period in ferret embryonic development when apical RGCs generate a burst of bRGCs that become founders of the OSVZ. After this period, bRGCs in the OSVZ proliferate and self-renew exclusively locally, thereby forming a self-sustained lineage independent from the other germinal layers. The time window for the brief period of OSVZ bRGC production is delineated by the coincident downregulation of Cdh1 and Trnp1, and their upregulation reduces bRGC production and prevents OSVZ seeding. This mechanism in cortical development may have key relevance in brain evolution and disease.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Mammalian Cerebral-cortex; Radial Glia; In-vivo; Human Neocortex; Spindle Orientation; Progenitor Cells; Visual-cortex; Lissencephalic Primate; Cortical Neurogenesis; Embryonic Neocortex
ISSN (print) / ISBN
2041-1723
e-ISSN
2041-1723
Journal
Nature Communications
Quellenangaben
Volume: 7,
Article Number: 11812
Publisher
Nature Publishing Group
Publishing Place
London
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)