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Opposing effects of antidiabetic interventions on malignant growth and metastasis.
Cell Metab. 23, 959-960 (2016)
Publ. Version/Full Text
DOI
PMC
Type 2 diabetes is associated with increased risk of malignancies, whereas antidiabetic interventions like physical exercise or metformin reduce cancer incidence. A recent publication shows that one diabetes treatment approach, namely incretin-related DPP4 inhibitors, increases metastatic capacity by activating the antioxidant transcription factor NRF2 to decrease reactive oxygen species (ROS) levels.
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Publication type
Article: Journal article
Document type
Other: News Item
Keywords
Transcription
ISSN (print) / ISBN
1550-4131
e-ISSN
1932-7420
Journal
Cell Metabolism
Quellenangaben
Volume: 23,
Issue: 6,
Pages: 959-960
Publisher
Elsevier
Publishing Place
Cambridge
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Obesity (IDO)