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Alexaki, V.I.* ; Chavakis, T.

The role of innate immunity in the regulation of brown and beige adipogenesis.

Rev. Endocr. Metab. Disord. 17, 41-49 (2016)
Postprint DOI
Open Access Green
The adipose tissue (AT) is multifunctional, acting as an endocrine tissue and participating in the regulation of the organism's homeostasis. Metabolic, endocrine and inflammatory mechanisms are tightly intertwined within the AT, regulating its function. Disruption of the equilibrium among these mechanisms leads to pathologies, the most common being obesity-related insulin resistance. Two types of AT exist, the white and the brown AT. Traditionally the white AT (WAT) was thought to store energy in the form of lipids, while the brown AT (BAT) was known to mediate heat generation. Recently, the 'brite' or 'beige' AT was identified, which is localized predominantly in subcutaneous WAT, but shares functional features with the BAT and is capable of heat production. The major stimulus triggering beige and brown adipogenesis is cold exposure and catecholamine signalling. However, several further signals and mechanisms exist, which can orchestrate and fine-tune beige and brown AT function. Immune cells and inflammation have emerged as regulators of beige and brown AT function. The present review will focus on the recently identified crosstalk between innate immunity and the regulation of beige and brown adipogenesis.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Innate Immunity ; Type 2 Immunity ; Inflammation ; Brown Adipose Tissue ; Beige Adipose Tissue; Adipose-tissue Inflammation; Diet-induced Obesity; Alternatively Activated Macrophages; Induced Insulin-resistance; Uncoupling Protein Gene; Adaptive Thermogenesis; Tnf-alpha; Mitochondrial Biogenesis; Orchestrate Development; Metabolic Dysfunction
ISSN (print) / ISBN 1389-9155
e-ISSN 1573-2606
Journal Reviews in Endocrine & Metabolic Disorders
Quellenangaben Volume: 17, Issue: 1, Pages: 41-49 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Boston
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)