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Follicular helper T cells in autoimmunity.
Curr. Diab. Rep. 16:75 (2016)
The development of multiple disease-relevant autoantibodies is a hallmark of autoimmune diseases. In autoimmune type 1 diabetes (T1D), a variable time frame of autoimmunity precedes the clinically overt disease. The relevance of T follicular helper (TFH) cells for the immune system is increasingly recognized. Their pivotal contribution to antibody production by providing help to germinal center (GC) B cells facilitates the development of a long-lived humoral immunity. Their complex differentiation process, involving various stages and factors like B cell lymphoma 6 (Bcl6), is strictly controlled, as anomalous regulation of TFH cells is connected with immunopathologies. While the adverse effects of a TFH cell-related insufficient humoral immunity are obvious, the role of increased TFH frequencies in autoimmune diseases like T1D is currently highlighted. High levels of autoantigen trigger an excessive induction of TFH cells, consequently resulting in the production of autoantibodies. Therefore, TFH cells might provide promising approaches for novel therapeutic strategies.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Autoantibodies ; Autoimmunity ; Biomarker ; Tfh Cells ; Type 1 Diabetes; Systemic-lupus-erythematosus; Cxc Chemokine Receptor-5; B-cells; In-vivo; Negative Regulator; Germinal-centers; Virus-infection; Mouse Model; Differentiation; Icos
ISSN (print) / ISBN
1534-4827
e-ISSN
1539-0829
Journal
Current Diabetes Reports
Quellenangaben
Volume: 16,
Issue: 8,
Article Number: 75
Publisher
Springer
Publishing Place
Heidelberg [u.a.]
Non-patent literature
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Reviewing status
Peer reviewed