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Scherm, M.G. ; Ott, V. ; Daniel, C.

Follicular helper T cells in autoimmunity.

Curr. Diab. Rep. 16:75 (2016)
Postprint DOI PMC
Open Access Green
The development of multiple disease-relevant autoantibodies is a hallmark of autoimmune diseases. In autoimmune type 1 diabetes (T1D), a variable time frame of autoimmunity precedes the clinically overt disease. The relevance of T follicular helper (TFH) cells for the immune system is increasingly recognized. Their pivotal contribution to antibody production by providing help to germinal center (GC) B cells facilitates the development of a long-lived humoral immunity. Their complex differentiation process, involving various stages and factors like B cell lymphoma 6 (Bcl6), is strictly controlled, as anomalous regulation of TFH cells is connected with immunopathologies. While the adverse effects of a TFH cell-related insufficient humoral immunity are obvious, the role of increased TFH frequencies in autoimmune diseases like T1D is currently highlighted. High levels of autoantigen trigger an excessive induction of TFH cells, consequently resulting in the production of autoantibodies. Therefore, TFH cells might provide promising approaches for novel therapeutic strategies.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Autoantibodies ; Autoimmunity ; Biomarker ; Tfh Cells ; Type 1 Diabetes; Systemic-lupus-erythematosus; Cxc Chemokine Receptor-5; B-cells; In-vivo; Negative Regulator; Germinal-centers; Virus-infection; Mouse Model; Differentiation; Icos
Language english
Publication Year 2016
HGF-reported in Year 2016
ISSN (print) / ISBN 1534-4827
e-ISSN 1539-0829
Journal Current Diabetes Reports
Quellenangaben Volume: 16, Issue: 8, Pages: , Article Number: 75 Supplement: ,
Publisher Springer
Publishing Place Heidelberg [u.a.]
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research (IDF)
Institute of Diabetes and Obesity (IDO)
POF-Topic(s) 90000 - German Center for Diabetes Research
30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-501900-213
G-501900-212
G-502200-001
DOI 10.1007/s11892-016-0770-2
WOS ID WOS:000381995900009
Scopus ID 84976311618
PubMed ID 27324759
Erfassungsdatum 2016-07-04
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