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Eigenspectra optoacoustic tomography achieves quantitative blood oxygenation imaging deep in tissues.
Nat. Commun. 7:12121 (2016)
Light propagating in tissue attains a spectrum that varies with location due to wavelength-dependent fluence attenuation, an effect that causes spectral corruption. Spectral corruption has limited the quantification accuracy of optical and optoacoustic spectroscopic methods, and impeded the goal of imaging blood oxygen saturation (sO2) deep in tissues; a critical goal for the assessment of oxygenation in physiological processes and disease. Here we describe light fluence in the spectral domain and introduce eigenspectra multispectral optoacoustic tomography (eMSOT) to account for wavelength-dependent light attenuation, and estimate blood sO2 within deep tissue. We validate eMSOT in simulations, phantoms and animal measurements and spatially resolve sO2 in muscle and tumours, validating our measurements with histology data. eMSOT shows substantial sO2 accuracy enhancement over previous optoacoustic methods, potentially serving as a valuable tool for imaging tissue pathophysiology.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
In-vivo; Tumor Hypoxia; Model; Microcirculation; Reconstruction; Microscopy; Contrast; Marker
Language
english
Publication Year
2016
HGF-reported in Year
2016
ISSN (print) / ISBN
2041-1723
e-ISSN
2041-1723
Journal
Nature Communications
Quellenangaben
Volume: 7,
Article Number: 12121
Publisher
Nature Publishing Group
Publishing Place
London
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)
Institute of Radiation Medicine (IRM)
Institute of Radiation Medicine (IRM)
POF-Topic(s)
30205 - Bioengineering and Digital Health
30203 - Molecular Targets and Therapies
30203 - Molecular Targets and Therapies
Research field(s)
Enabling and Novel Technologies
Radiation Sciences
Radiation Sciences
PSP Element(s)
G-505500-001
G-501300-001
G-501300-001
PubMed ID
27358000
WOS ID
WOS:000379114800001
Scopus ID
84977161109
Erfassungsdatum
2016-07-04