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Open Access Green as soon as Postprint is submitted to ZB.
Novel phenotypes of prediabetes?
Diabetologia 59, 1806-1818 (2016)
This article describes phenotypes observed in a prediabetic population (i.e. a population with increased risk for type 2 diabetes) from data collected at the University hospital of Tübingen. We discuss the impact of genetic variation on insulin secretion, in particular the effect on compensatory hypersecretion, and the incretin-resistant phenotype of carriers of the gene variant TCF7L2 is described. Imaging studies used to characterise subphenotypes of fat distribution, metabolically healthy obesity and metabolically unhealthy obesity are described. Also discussed are ectopic fat stores in liver and pancreas that determine the phenotype of metabolically healthy and unhealthy fatty liver and the recently recognised phenotype of fatty pancreas. The metabolic impact of perivascular adipose tissue and pancreatic fat is discussed. The role of hepatokines, particularly that of fetuin-A, in the crosstalk between these organs is described. Finally, the role of brain insulin resistance in the development of the different prediabetes phenotypes is discussed.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Brain Insulin Resistance ; Insulin ; Liver Fat ; Phenotype ; Prediabetes ; Review ; Secretion ; Sensitivity; Life-style Intervention; Beta-cell Function; Type-2 Diabetes-mellitus; Fatty Liver-disease; Peptide-1-induced Insulin-secretion; Impaired Glucose-tolerance; Central-nervous-system; Acid Receptor 1; Fetuin-a Levels; Perivascular Fat
ISSN (print) / ISBN
0012-186X
e-ISSN
1432-0428
Journal
Diabetologia
Quellenangaben
Volume: 59,
Issue: 9,
Pages: 1806-1818
Publisher
Springer
Publishing Place
Berlin ; Heidelberg [u.a.]
Reviewing status
Peer reviewed