PuSH - Publication Server of Helmholtz Zentrum München: Selenium and prostate cancer: Analysis of individual participant data from fifteen prospective studies.

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

EVA: Electronic Publishing

New EVA Application

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Allen, N.E.* ; Travis, R.C.* ; Appleby, P.N.* ; Albanes, D.* ; Barnett, M.J.* ; Black, A.* ; Bueno-de-Mesquita, H.B.* ; Deschasaux, M.* ; Galan, P.* ; Goodman, G.E.* ; Goodman, P.J.* ; Gunter, M.J.* ; Heliövaara, M.* ; Helzlsouer, K.J.* ; Henderson, B.E.* ; Hercberg, S.* ; Knekt, P.* ; Kolonel, L.N.* ; Lasheras, C.* ; Linseisen, J. ; Metter, E.J.* ; Neuhouser, M.L.* ; Olsen, A.* ; Pala, V.* ; Platz, E.A.* ; Rissanen, H.* ; Reid, M.E.* ; Schenk, J.M.* ; Stampfer, M.J.* ; Stattin, P.* ; Tangen, C.M.* ; Touvier, M.* ; Trichopoulou, A.* ; van den Brandt, P.A.* ; Key, T.J.*

Selenium and prostate cancer: Analysis of individual participant data from fifteen prospective studies.

J. Natl. Cancer Inst. 108:djw153 (2016)

Publ. Version/Full Text

DOI

PMC

	Open Access Hybrid

Abstract
Metrics
Extra information

BACKGROUND: Some observational studies suggest that a higher selenium status is associated with a lower risk of prostate cancer but have been generally too small to provide precise estimates of associations, particularly by disease stage and grade. METHODS: Collaborating investigators from 15 prospective studies provided individual-participant records (from predominantly men of white European ancestry) on blood or toenail selenium concentrations and prostate cancer risk. Odds ratios of prostate cancer by selenium concentration were estimated using multivariable-adjusted conditional logistic regression. All statistical tests were two-sided. RESULTS: Blood selenium was not associated with the risk of total prostate cancer (multivariable-adjusted odds ratio [OR] per 80 percentile increase = 1.01, 95% confidence interval [CI] = 0.83 to 1.23, based on 4527 case patients and 6021 control subjects). However, there was heterogeneity by disease aggressiveness (ie, advanced stage and/or prostate cancer death, Pheterogeneity = .01), with high blood selenium associated with a lower risk of aggressive disease (OR = 0.43, 95% CI = 0.21 to 0.87) but not with nonaggressive disease. Nail selenium was inversely associated with total prostate cancer (OR = 0.29, 95% CI = 0.22 to 0.40, Ptrend < .001, based on 1970 case patients and 2086 control subjects), including both nonaggressive (OR = 0.33, 95% CI = 0.22 to 0.50) and aggressive disease (OR = 0.18, 95% CI = 0.11 to 0.31, Pheterogeneity = .08). CONCLUSIONS: Nail, but not blood, selenium concentration is inversely associated with risk of total prostate cancer, possibly because nails are a more reliable marker of long-term selenium exposure. Both blood and nail selenium concentrations are associated with a reduced risk of aggressive disease, which warrants further investigation.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

11.370

3.049