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Ionoacoustic tomography of the proton Bragg peak in combination with ultrasound and optoacoustic imaging.
Sci. Rep. 6:29305 (2016)
Ions provide a more advantageous dose distribution than photons for external beam radiotherapy, due to their so-called inverse depth dose deposition and, in particular a characteristic dose maximum at their end-of-range (Bragg peak). The favorable physical interaction properties enable selective treatment of tumors while sparing surrounding healthy tissue, but optimal clinical use requires accurate monitoring of Bragg peak positioning inside tissue. We introduce ionoacoustic tomography based on detection of ion induced ultrasound waves as a technique to provide feedback on the ion beam profile. We demonstrate for 20 MeV protons that ion range imaging is possible with submillimeter accuracy and can be combined with clinical ultrasound and optoacoustic tomography of similar precision. Our results indicate a simple and direct possibility to correlate, in-vivo and in real-time, the conventional ultrasound echo of the tumor region with ionoacoustic tomography. Combined with optoacoustic tomography it offers a well suited pre-clinical imaging system.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Positron-emission-tomography; Computed-tomography; In-vivo; Photoacoustic Microscopy; Plasma Accelerators; Range Uncertainties; Therapy; Beam; Simulation; Verification
Language
english
Publication Year
2016
HGF-reported in Year
2016
ISSN (print) / ISBN
2045-2322
e-ISSN
2045-2322
Journal
Scientific Reports
Quellenangaben
Volume: 6,
Article Number: 29305
Publisher
Nature Publishing Group
Publishing Place
London
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s)
30205 - Bioengineering and Digital Health
Research field(s)
Enabling and Novel Technologies
PSP Element(s)
G-505500-001
PubMed ID
27384505
WOS ID
WOS:000379145700001
Scopus ID
84977660253
Erfassungsdatum
2016-07-09