Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
Postprint
Research data
DOI
PMC
 |
Open Access Green |
as soon as is submitted to ZB.
Ghrelin modulates encoding-related brain function without enhancing memory formation in humans.
Neuroimage 142, 465-473 (2016)
Ghrelin regulates energy homeostasis in various species and enhances memory in rodent models. In humans, the role of ghrelin in cognitive processes has yet to be characterized. Here we show in a double-blind randomized crossover design that acute administration of ghrelin alters encoding-related brain activity, however does not enhance memory formation in humans. Twenty-one healthy young male participants had to memorize food- and non-food-related words presented on a background of a virtual navigational route while undergoing fMRI recordings. After acute ghrelin administration, we observed decreased post-encoding resting state fMRI connectivity between the caudate nucleus and the insula, amygdala, and orbitofrontal cortex. In addition, brain activity related to subsequent memory performance was modulated by ghrelin. On the next day, however, no differences were found in free word recall or cued location-word association recall between conditions; and ghrelin's effects on brain activity or functional connectivity were unrelated to memory performance. Further, ghrelin had no effect on a cognitive test battery comprising tests for working memory, fluid reasoning, creativity, mental speed, and attention. In conclusion, in contrast to studies with animal models, we did not find any evidence for the potential of ghrelin acting as a short-term cognitive enhancer in humans.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Cognition ; Enhancement ; Functional Connectivity ; Ghrelin ; Memory ; Resting State; Adult Hippocampal Neurogenesis; Stimulated Insulin-secretion; Alzheimers-disease; Orbitofrontal Cortex; Healthy Humans; Food; Amygdala; Appetite; System; Rats
ISSN (print) / ISBN
1053-8119
e-ISSN
1095-9572
Quellenangaben
Volume: 142,
Pages: 465-473
Publisher
Elsevier
Publishing Place
San Diego
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Obesity (IDO)