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Pathology and biology of radiation-induced cardiac disease.

J. Radiat. Res. 57, 439-448 (2016)
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Heart disease is the leading global cause of death. The risk for this disease is significantly increased in populations exposed to ionizing radiation, but the mechanisms are not fully elucidated yet. This review aims to gather and discuss the latest data about pathological and biological consequences in the radiation-exposed heart in a comprehensive manner. A better understanding of the molecular and cellular mechanisms underlying radiation-induced damage in heart tissue and cardiac vasculature will provide novel targets for therapeutic interventions. These may be valuable for individuals clinically or occupationally exposed to varying doses of ionizing radiation.
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Publication type Article: Journal article
Document type Review
Keywords Cardiac Disease ; Endothelial Cell ; Heart ; Ionizing Radiation ; Myocardium; Induced Heart-disease; Inflammatory Plaque Phenotype; Human Endothelial-cells; Von-willebrand-factor; Ionizing-radiation; Cardiovascular-disease; Apoe(-/-) Mice; Breast-cancer; Rat-heart; In-vitro
Language german
Publication Year 2016
HGF-reported in Year 2016
ISSN (print) / ISBN 0449-3060
e-ISSN 1349-9157
Quellenangaben Volume: 57, Issue: 5, Pages: 439-448 Article Number: , Supplement: ,
Publisher Oxford University Press
Publishing Place Oxford
Reviewing status Peer reviewed
POF-Topic(s) 30202 - Environmental Health
Research field(s) Radiation Sciences
PSP Element(s) G-500200-001
PubMed ID 27422929
Scopus ID 84992209656
Erfassungsdatum 2016-07-26