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Pathology and biology of radiation-induced cardiac disease.
J. Radiat. Res. 57, 439-448 (2016)
Heart disease is the leading global cause of death. The risk for this disease is significantly increased in populations exposed to ionizing radiation, but the mechanisms are not fully elucidated yet. This review aims to gather and discuss the latest data about pathological and biological consequences in the radiation-exposed heart in a comprehensive manner. A better understanding of the molecular and cellular mechanisms underlying radiation-induced damage in heart tissue and cardiac vasculature will provide novel targets for therapeutic interventions. These may be valuable for individuals clinically or occupationally exposed to varying doses of ionizing radiation.
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Publication type
Article: Journal article
Document type
Review
Keywords
Cardiac Disease ; Endothelial Cell ; Heart ; Ionizing Radiation ; Myocardium; Induced Heart-disease; Inflammatory Plaque Phenotype; Human Endothelial-cells; Von-willebrand-factor; Ionizing-radiation; Cardiovascular-disease; Apoe(-/-) Mice; Breast-cancer; Rat-heart; In-vitro
ISSN (print) / ISBN
0449-3060
e-ISSN
1349-9157
Journal
Journal of Radiation Research
Quellenangaben
Volume: 57,
Issue: 5,
Pages: 439-448
Publisher
Oxford University Press
Publishing Place
Oxford
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Radiation Biology (ISB)