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Direct neuronal reprogramming: Learning from and for development.
Development 143, 2494-2510 (2016)
Publ. Version/Full Text
DOI
PMC
The key signalling pathways and transcriptional programmes that instruct neuronal diversity during development have largely been identified. In this Review, we discuss how this knowledge has been used to successfully reprogramme various cell types into an amazing array of distinct types of functional neurons. We further discuss the extent to which direct neuronal reprogramming recapitulates embryonic development, and examine the particular barriers to reprogramming that may exist given a cell's unique developmental history. We conclude with a recently proposed model for cell specification called the 'Cook Islands' model, and consider whether it is a fitting model for cell specification based on recent results from the direct reprogramming field.
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Publication type
Article: Journal article
Document type
Review
Keywords
Conversion ; Direct Reprogramming ; Neurogenesis ; Neuron ; Neuronal Subtype ; Transcription Factor ; Transdifferentiation; Embryonic Stem-cells; Pioneer Transcription Factors; Mammalian Cerebral-cortex; Spinal Motor-neurons; Human Fibroblasts; Direct Conversion; Functional-neurons; Neural Stem; In-vivo; Dopaminergic-neurons
ISSN (print) / ISBN
0950-1991
e-ISSN
1477-9129
Quellenangaben
Volume: 143,
Issue: 14,
Pages: 2494-2510
Publisher
Company of Biologists
Publishing Place
Cambridge
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)