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Lymphocyte signaling and activation by the CARMA1-BCL10-MALT1 signalosome.
Biol. Chem. 397, 1315-1333 (2016)
The CARMA1-BCL10-MALT1 (CBM) signalosome triggers canonical NF-κB signaling and lymphocyte activation upon antigen receptor stimulation. Genetic studies in mice and the analysis of human immune pathologies unveiled a critical role of the CBM complex in adaptive immune responses. Great progress has been made in elucidating the fundamental mechanisms that dictate CBM assembly and disassembly. By bridging proximal antigen receptor signaling to downstream signaling pathways, the CBM complex exerts a crucial scaffolding function. Moreover, the MALT1 subunit confers a unique proteolytic activity that is key for lymphocyte activation. Deregulated 'chronic' CBM signaling drives constitutive NF-κB signaling and MALT1 activation, which contribute to the development of autoimmune and inflammatory diseases as well as lymphomagenesis. Thus, the processes that govern CBM activation and function are promising targets for the treatment of immune disorders. Here, we summarize the current knowledge on the functions and mechanisms of CBM signaling in lymphocytes and how CBM deregulations contribute to aberrant signaling in malignant lymphomas.
Impact Factor
Scopus SNIP
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Times Cited
Times Cited
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2.710
0.751
37
37
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Publication type
Article: Journal article
Document type
Review
Keywords
Adaptive Immunity ; Cbm Complex ; Diffuse Large B Cell Lymphomas ; Lymphocyte Signaling; Nf-kappa-b; T-cell-activation; Malt1 Protease Activity; Responsive Inhibitory Domain; Oncogenic Card11 Mutations; Messenger-rna Decay; Kinase-c-theta; Paracaspase Malt1; Antigen-receptor; Immune-responses
Language
english
Publication Year
2016
HGF-reported in Year
2016
ISSN (print) / ISBN
1431-6730
e-ISSN
1437-4315
Journal
Biological Chemistry
Quellenangaben
Volume: 397,
Issue: 12,
Pages: 1315-1333
Publisher
de Gruyter
Publishing Place
Berlin
Reviewing status
Peer reviewed
Institute(s)
Research Unit Signaling and Translation (SAT)
POF-Topic(s)
30203 - Molecular Targets and Therapies
Research field(s)
Enabling and Novel Technologies
PSP Element(s)
G-509800-002
WOS ID
WOS:000387888700013
Scopus ID
84994559780
PubMed ID
27420898
Erfassungsdatum
2016-07-29