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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Interleukin-22 is elevated in lavage from patients with lung cancer and other pulmonary diseases.
BMC Cancer 16:409 (2016)
Background: Interleukin-22 (IL-22) is involved in lung diseases such as pneumonia, asthma and lung cancer. Lavage mirrors the local environment, and may provide insights into the presence and role of IL-22 in patients. Methods: Bronchoscopic lavage (BL) samples (n = 195, including bronchoalveolar lavage and bronchial washings) were analysed for IL-22 using an enzyme-linked immunosorbent assay. Clinical characteristics and parameters from lavage and serum were correlated with lavage IL-22 concentrations. Results: IL-22 was higher in lavage from patients with lung disease than in controls (38.0 vs 15.3 pg/ml, p < 0.001). Patients with pneumonia and lung cancer had the highest concentrations (48.9 and 33.0 pg/ml, p = 0.009 and p < 0.001, respectively). IL-22 concentration did not correlate with systemic inflammation. IL-22 concentrations did not relate to any of the analysed cell types in BL indicating a potential mixed contribution of different cell populations to IL-22 production. Conclusions: Lavage IL-22 concentrations are high in patients with lung cancer but do not correlate with systemic inflammation, thus suggesting that lavage IL-22 may be related to the underlying malignancy. Our results suggest that lavage may represent a distinct compartment where the role of IL-22 in thoracic malignancies can be studied.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Bronchoalveolar Lavage ; Interleukin-22 ; Biomarker ; Lung Cancer ; Pneumonia; Community-acquired Pneumonia; T-cells; Bronchoalveolar Lavage; Il-22; Subsets; Defense; Injury; Th22
Language
english
Publication Year
2016
HGF-reported in Year
0
ISSN (print) / ISBN
1471-2407
e-ISSN
1471-2407
Journal
BMC Cancer
Quellenangaben
Volume: 16,
Article Number: 409
Publisher
BioMed Central
Publishing Place
London
Reviewing status
Peer reviewed
Institute(s)
Institute of Lung Health and Immunity (LHI)
POF-Topic(s)
30202 - Environmental Health
Research field(s)
Lung Research
PSP Element(s)
G-501600-001
G-505000-001
G-505000-001
WOS ID
WOS:000379205800001
Erfassungsdatum
2016-07-29