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Di-(2-propylheptyl) phthalate (DPHP) and its metabolites in blood of rats upon single oral administration of DPHP.
Toxicol. Lett. 259, 80-86 (2016)
Di-(2-propylheptyl) phthalate (DPHP) does not act as a reproductive toxicant or endocrine disruptor in contrast to other phthalates. Considering adverse effects of phthalates to be linked to their metabolism, it was the aim of the present study to investigate in the rat the blood burden of DPHP and its metabolites as a basis for understanding the toxicological behavior of DPHP. Rats were administered single oral doses of DPHP of 0.7 and 100mg/kg body weight. Concentration-time courses of DPHP and metabolites were monitored in blood. The areas under the concentration-time curves in blood (AUCs), normalized for the dose of DPHP, showed the following order: DPHP
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Di-(2-propylheptyl) Phthalate ; Blood ; Metabolites ; Oral Treatment ; Rat; Di(2-ethylhexyl) Phthalate; Di-(2-ethylhexyl) Phthalate; 2-ethylhexyl Phthalate; Male-volunteers; Disposition; Hydrolysis; Marmosets; Esters; Dehp; Excretion
ISSN (print) / ISBN
0378-4274
e-ISSN
1879-3169
Journal
Toxicology Letters
Quellenangaben
Volume: 259,
Pages: 80-86
Publisher
Elsevier
Publishing Place
Amsterdam
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Reviewing status
Peer reviewed