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Altered relation of the renin-aldosterone system and vasoactive peptides in type 2 diabetes: The KORA F4 study.
Atherosclerosis 252, 88-96 (2016)
BACKGROUND AND AIMS: The exact mechanism of premature atherosclerosis in diabetes is still unclear. Inappropriate activation of the renin-aldosterone-angiotensin system may be an important risk factor for cardiovascular disease. We investigated whether renin and aldosterone are associated with vasoactive peptides midregional-pro atrial natriuretic peptide (MR-proANP) and midregional-pro adrenomedullin (MR-proADM), or with intima media thickness (IMT) as a marker for early atherosclerotic alterations in the general community and in subjects with type 2 diabetes. METHODS: In 1261 participants in the KORA F4 study, the associations of renin, aldosterone and aldosterone to renin ratio with MR-proANP, MR-proADM and IMT were assessed using linear regression models stratified for the presence of prediabetes and type 2 diabetes. RESULTS: After adjustment for confounding factors, an inverse association of MR-proANP with renin (p = 0.002) and aldosterone (p = 0.021) and a direct association of MR-proADM with renin (p < 0.001) and aldosterone (p = 0.019) were seen in nondiabetic individuals. In diabetic subjects, there was no significant correlation of MR-proANP or MR-proADM with renin or aldosterone. Renin and aldosterone were not directly associated with IMT in non-diabetic subjects and the total cohort, whereas aldosterone was associated with IMT in diabetic participants (p = 0.005). CONCLUSIONS: This study shows associations between renin, aldosterone and MR-proANP/MR-proADM plasma levels that are altered in type 2 diabetes. Plasma renin and aldosterone are not independent biomarkers for early atherosclerotic damages of the carotid arteries in the general community.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Anp ; Adrenomedullin ; Aldosterone ; Diabetes ; Mr-proadm ; Mr-proanp ; Renin; Intima-media Thickness; Atrial-natriuretic-peptide; Cardiovascular Events; Essential-hypertension; Arterial Stiffness; Plasma-aldosterone; General Community; Carotid-artery; Heart-failure; Adrenomedullin
ISSN (print) / ISBN
0021-9150
e-ISSN
1879-1484
Journal
Atherosclerosis
Quellenangaben
Volume: 252,
Pages: 88-96
Publisher
Elsevier
Publishing Place
Amsterdam
Non-patent literature
Publications
Reviewing status
Peer reviewed