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Translational research in pleural infection and beyond.
Chest 150, 1361-1370 (2016)
The incidence of pleural infection has been rising in recent years. Intrapleural therapy with tissue plasminogen activator (tPA) and deoxyribonuclease (DNase) has significantly reduced the need of surgery and its impact on clinical care is rising worldwide. Efforts are underway to optimize the delivery regime and establish the short and longer term effects of this therapy. The complex interactions of bacterial infection within the pleura with inflammatory responses and clinical interventions (antibiotics and tPA/DNase) require further studies to improve future treatment options. Intrapleural instillation of tPA potently induces pleural fluid formation, principally via a monocyte chemotactic protein (MCP)-1 dependent mechanism. Activation of transcriptional programs in pleural resident cells and infiltrating cells during pleural infection and malignancy results in the local secretion of a cocktail of pro-inflammatory signalling molecules (including MCP-1) within the pleural confines that contributes to effusion formation. Understanding the biology of these molecules and their interaction may provide novel targets for pleural fluid control.
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2.812
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Ccl2 ; Translating Basic Research Into Clinical Practice ; Fibrinolysis ; Infection ; Inflammation ; Lung Cancer ; Pneumonia; Nf-kappa-b; Tissue-plasminogen Activator; Complicated Parapneumonic Effusions; Growth-factor Levels; Cell Lung-cancer; Intrapleural Streptokinase; Mesothelial Cells; Fibrinolytic Therapy; Controlled-trial; T-cells
Language
english
Publication Year
2016
HGF-reported in Year
2016
ISSN (print) / ISBN
0012-3692
e-ISSN
1931-3543
Journal
Chest
Quellenangaben
Volume: 150,
Issue: 6,
Pages: 1361-1370
Publisher
American College of Chest Physicians
Publishing Place
Glenview
Reviewing status
Peer reviewed
Institute(s)
Institute of Lung Health and Immunity (LHI)
POF-Topic(s)
30202 - Environmental Health
Research field(s)
Lung Research
PSP Element(s)
G-501600-003
WOS ID
WOS:000392274600035
PubMed ID
27521736
Erfassungsdatum
2016-09-02