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Olefir, I. ; Mercep, E. ; Burton, N.C.* ; Ovsepian, S.V. ; Ntziachristos, V.

Hybrid multispectral optoacoustic and ultrasound tomography for morphological and physiological brain imaging.

J. Biomed. Opt. 21:86005 (2016)
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Open Access Gold
Expanding usage of small animal models in biomedical research necessitates development of technologies for structural, functional, or molecular imaging that can be readily integrated in the biological laboratory. Herein, we consider dual multispectral optoacoustic (OA) and ultrasound tomography based on curved ultrasound detector arrays and describe the performance achieved for hybrid morphological and physiological brain imaging of mice in vivo. We showcase coregistered hemodynamic parameters resolved by OA tomography under baseline conditions and during alterations of blood oxygen saturation. As an internal reference, we provide imaging of abdominal organs. We illustrate the performance advantages of hybrid curved detector ultrasound and OA tomography and discuss immediate and long-term implications of our findings in the context of animal and human studies.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Brain Tomography ; Hybrid Systems ; In Vivo Imaging ; Multispectral Optoacoustic Tomography ; Oxygen Saturation ; Photoacoustic; Ray Computed-tomography; In-vivo; Photoacoustic Tomography; Transducer Array; Contrast Agent; Pet/ct Scanner; Microscopy; Mri; Nanoparticles; Multiphoton
Language
Publication Year 2016
HGF-reported in Year 2016
ISSN (print) / ISBN 1083-3668
e-ISSN 1560-2281
Journal Journal of Biomedical Optics
Quellenangaben Volume: 21, Issue: 8, Pages: , Article Number: 86005 Supplement: ,
Publisher SPIE
Publishing Place Bellingham
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505500-001
DOI 10.1117/1.JBO.21.8.086005
WOS ID WOS:000388212300030
Scopus ID 84982315640
PubMed ID 27533442
Erfassungsdatum 2016-08-25
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