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Open Access Green as soon as Postprint is submitted to ZB.
Hybrid multispectral optoacoustic and ultrasound tomography for morphological and physiological brain imaging.
J. Biomed. Opt. 21:86005 (2016)
Expanding usage of small animal models in biomedical research necessitates development of technologies for structural, functional, or molecular imaging that can be readily integrated in the biological laboratory. Herein, we consider dual multispectral optoacoustic (OA) and ultrasound tomography based on curved ultrasound detector arrays and describe the performance achieved for hybrid morphological and physiological brain imaging of mice in vivo. We showcase coregistered hemodynamic parameters resolved by OA tomography under baseline conditions and during alterations of blood oxygen saturation. As an internal reference, we provide imaging of abdominal organs. We illustrate the performance advantages of hybrid curved detector ultrasound and OA tomography and discuss immediate and long-term implications of our findings in the context of animal and human studies.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Brain Tomography ; Hybrid Systems ; In Vivo Imaging ; Multispectral Optoacoustic Tomography ; Oxygen Saturation ; Photoacoustic; Ray Computed-tomography; In-vivo; Photoacoustic Tomography; Transducer Array; Contrast Agent; Pet/ct Scanner; Microscopy; Mri; Nanoparticles; Multiphoton
ISSN (print) / ISBN
1083-3668
e-ISSN
1560-2281
Journal
Journal of Biomedical Optics
Quellenangaben
Volume: 21,
Issue: 8,
Article Number: 86005
Publisher
SPIE
Publishing Place
Bellingham
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)